ACTA1 and fibrosis: Several pieces of evidence demonstrate (1) that deprivation of E-cadherin, which is expressed in epithelial cells, can result in EMT (2) that EMT can arise from overexpression of α-SMA in vascular smooth muscle cells and myoepithelial cells and (3) Snail is conceived to subdue the expression of E-cadherin.[45, 46] As judged by our data, the prevention of EMT by oral administration of TL could also lead to the reduction of cGVHD-elicited fibrosis.