TP53 and neoplasm: This is likely due to three primary causes: 1) inadequate nutrient supply to tumor cells as a consequence of imbalance between tumor growth and angiogenesis; 2) a cytotoxic immune response to apoptosis‐resistant tumors; and 3) tumor's primary deficiencies in programmed (apoptotic) cell death due to defects in p53 associated pathways, upregulation of BCL2 anti‐apoptotic proteins, and exaggerated autophagy “programmed cell survival.”