AKT1 and neoplasm: Pathway enrichment analysis of genes with losses and gains among the SPN cases (SPN11, SPN13, SPN14 and SPN56) showed that altered genes are involved in metabolic and pro‐proliferative pathways, such as central carbon metabolism, Rap1, Ras, Pi3K/Akt, mTOR and focal adhesion, all of which are known to be involved in tumour progression 20, 21, 22, 23, 24, 25 (see supplementary material, Tables S6A,B).