Previous studies indicate that PRE-084 (Sig1R agonist) may have neuroprotective antioxidant properties and a beneficial role in HIV-1 infection (Nguyen et al. 2014; Katnik et al. 2006: Allahtavakoli and Jarrott 2011), experiments were also performed to test its effect on HIV-1 infection levels and CATB secretion. This evidence concerns the gene TYRP1 and HIV-1 infection.