The involvement of oxidative and nitrosative stress in MDD is confirmed by the increased oxidative (such as NO, arachidonic acid, malondialdehyde, and 8-hydroxy-2-deoxyguanosine) and nitrosative (such as immunoglobulin (M IgM)- antibodies directed against phosphatidylitol and nitro-bovine serum albumin) stress markers in MDD patients, together with decreased levels of antioxidants (such as vitamins C and E) [160–164]. This evidence concerns the gene CD40LG and major depressive disorder.