KLK3 and metastatic neoplasm: First, given the composite characterization of advanced prostate cancer in the summary GWAS data that we obtained (Gleason ≥ 8, prostate-specific antigen > 100 ng/mL, metastatic disease (M1), or death from prostate cancer), it is difficult to directly compare our findings with those from prospective studies that examined associations between calcium and fatal prostate cancer.