First, given the composite characterization of advanced prostate cancer in the summary GWAS data that we obtained (Gleason ≥ 8, prostate-specific antigen > 100 ng/mL, metastatic disease (M1), or death from prostate cancer), it is difficult to directly compare our findings with those from prospective studies that examined associations between calcium and fatal prostate cancer. Here, KLK3 is linked to Familial prostate cancer.