For corneal astigmatism, the nearest gene at each of the four genome-wide significant loci was ZC3H11B (top marker: rs12032649, P = 5.00 × 10−14), LINC00340 (top marker: rs196052, P = 7.80 × 10−11), HERC2 (top marker: rs1129038, P = 1.10 × 10−15) and TSPAN10/NPLOC4 (top marker: rs62075722, P = 2.20 × 10−13) (Table 1). The gene discussed is NPLOC4; the disease is Corneal astigmatism.