CASC15 and Corneal astigmatism: Additional sensitivity analyses were performed using logistic regression for the same groups of individuals and covariates as analysed by linear regression, with cases defined as individuals with corneal or refractive astigmatism ≥ 1.00 D. Here, three of the four previously identified loci, near the genes ZC3H11B, HERC2 and TSPAN10/NPLOC4, demonstrated genome-wide significant association for corneal astigmatism, while only the LINC00340 locus continued to demonstrate genome-wide significant association for refractive astigmatism (Online Resources 9, 10, 11b, 11d, 12b and 12d).