Two of the transcripts, FOXA1 (known for its upregulation and pro-metastatic action in pancreatic cancer) and the putative tumor suppressor FOXO6, [35–37] showed metarrestin exposure-dependent expression changes in KPC tumors (Fig. 4c) and in cultured mouse and human pancreatic cancer cell lines (Fig. 4d). Here, FOXO6 is linked to familial pancreatic carcinoma.