PDX1 and pancreatic neoplasm: In this study, we define the PK and PK/PD relationship of metarrestin (ML-246) in the plasma, healthy tissues, and pancreatic tumors of wild-type and KPC (transgenic Ras-driven Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ pancreas cancer model) mice.