These include the metastasis enhancer FOXA1 and the putative tumor suppressor FOXO6. Interestingly, the known role of FOXA1 in the metastatic transition of pancreas cancer, originally identified in the KPC animal model used in this study, and the tumor suppressor functions of FOXO6 in lung cancer cells provide biologically plausible links to the anti-metastatic phenotype of metarrestin [35–37]. Here, FOXA1 is linked to pancreatic neoplasm.