Increased systemic HMGB1 levels, measured 3 h after hospital admission for STEMI, was also associated with reduced functional recovery after MI measured as heart rate recovery (HRR), peak oxygen consumption (VO2peack) and LV Ejection fraction (LVEF) determined 3–4 weeks after MI [134, 135]. Here, HMGB1 is linked to myocardial infarction.