INS and type 2 diabetes mellitus: Due to the mounting evidence on potential selection bias and the multi-faceted action of TCF7L2 variation on insulin and glucose biology [5, 6, 18], we aimed 1) to replicate the multivariable association between TCF7L2 T2D risk alleles and lower BMI in a population-based study of US Hispanic/Latinos accounting for key covariates, and 2) to model the structured pathways between rs7903146, at TCF7L2, BMI over time, and age of diabetes diagnosis.