In fact, individuals with impaired glucose tolerance and undiagnosed diabetes at examination had the greatest protective effect on BMI of T2D-risk alleles at TCF7L2. Forthcoming HCHS/SOL, or other prospective cohort follow up data will allow future investigators to explore the contemporaneous and interacting relationships between TCF7L2, BMI and T2D status across the adult life course. This evidence concerns the gene TCF7L2 and Impaired glucose tolerance.