Recent studies demonstrated the modifier role of NAT2 G857A, COX-2 rs20417, CYP2E1 RsaI, CYP1A2 154A>C, XPC Lys939Gln, XPA A23G and MutS T1036A on the effect of red meat consumption on CRC risk. The gene discussed is XPA; the disease is colorectal carcinoma.