Most notably, AKT1-Ser473 phosphorylation as well as levels of phospho-ERK1/2, phospho-mTOR, and phospho-p38MAPK were significantly elevated in the Mat-Ob group [259], suggesting an active role of mTOR in the development of cardiac hypertrophy upon diet-induced maternal obesity [259]. The gene discussed is AKT1; the disease is cardiac hypertrophy.