IL6 and Mycoplasma pneumoniae pneumonia: In addition, the production of IL-2, IL-4, IL-10, and IFN-γ by splenic lymphocytes has been detected in significant high levels in a gnotobiotic mice model of Mycoplasma pneumoniae pneumonia, and IL-1ß and IL-6 were upregulated in a novel mouse model immunized with MP extracts plus alum [13, 14].