CCN1 and Hypoglycemia: The signaling events preceding VEGF mRNA stabilization by hypoxia have also been studied, with stress activated protein kinases playing an essential role [24, 28, 37].We have recently expanded upon the VEGF studies and show that oxygen and glucose deprivation (hypoxia/hypoglycemia) synergize to induce the stabilization of a number of hypoxia-related mRNAs including VEGF, MYC, and CYR61 [25].