According to Heikkinen et al., genetic polymorphism of MMP-3 and vitamin D receptor found to be linked to initial periodontitis in Finnish adolescents, and aMMP-8 PoC/chair-side immunoassay PerioSafe® mouth-rinse test can be used for on-line PoC detection of initial periodontitis or preperiodontitis in adolescent patients with such type of genetic predisposition. This evidence concerns the gene VDR and periodontitis.