In general, LFS patients harbor germline mutations in the TP53 gene, which predispose to a wide spectrum of early-onset cancer development, including bone and soft tissue sarcomas, brain tumors, breast carcinomas, leukemias, and adrenal cortical carcinomas, and, thus defining the clinical spectrum of LFS and also of the Li-Fraumeni like (LFL) syndrome [8]. This evidence concerns the gene TP53 and Li-Fraumeni syndrome.