Furthermore, although IL-6 induces the Th2 response, which might be controlled by the presence of IFN-γ and the absence of IL-418, IL-6 also up-regulates the fibronectin α5β1 receptor, which is involved in the interaction of BCG with the urothelium19,20, which inhibits bladder tumor cell proliferation. Here, IL6 is linked to urinary bladder neoplasm.