While key stress oncoproteins associated with increased PCa cell survival in the presence of environmental stressors such as chemotherapeutic drugs have been identified and at times targeted in pre-clinical and clinical studies (e.g., CLU, LEDGF/p75, HSP27, PRDXs), there remains a need to understand the potential contribution of glucocorticoid signaling to the activation and upregulation of these proteins. This evidence concerns the gene CLU and posterior cortical atrophy.