As a first step in evaluating this hypothesis we focused on the contribution of GR signaling to the expression of the stress oncoproteins Clusterin (CLU) and Lens Epithelium-Derived Growth Factor p75 (LEDGF/p75), previously shown to be upregulated in response to standard PCa therapies, including taxane therapy18–28. The gene discussed is NR3C1; the disease is posterior cortical atrophy.