Oversampling cases with a family history of hematological malignancy, we genotyped 244 WM/LPL cases of European descent (Supplementary Table 1), including 98 unrelated cases (40%) from high-risk families, using the Illumina OmniExpress SNP microarray chip and selected controls previously genotyped on the OmniExpress or Omni2.511,12. Here, LPL is linked to hematologic disorder.