Aligning with a key role for the NLRP3 inflammasome in sustaining the human Th1 response, CD4+ T cells from patients that suffer from cryopyrin-associated periodic syndromes (CAPS) due to gain-of-function mutations in NLRP3, display also significantly increased IFN-γ production. Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.