Using a mouse model of pancreatic acinar carcinoma7:Ngn3-Tsc1−/− transgenic mice in which tuberous sclerosis complex 1 (Tsc1) gene is deleted and mTORC1 signaling activated in neurogenin 3 (Ngn-3) positive cells, we here report that RYGB surgery blocks the spontaneous development of pancreatic cell acinar carcinomas (ACC). Here, TSC1 is linked to pancreatic acinar cell carcinoma.