Because the SIRT1 locus in humans is strongly associated with susceptibility to major depression45, and an increase in SIRT1 abundance in certain brain areas, such as the nucleus Accumbens, induces depressive-like behaviors in mice46, failure of brain SIRT1 expression to decrease in a timely fashion during the adolescence transition to adulthood might contribute to the well-known exacerbation of depressive disorders at puberty47, some of which occur in the context of obesity48. This evidence concerns the gene SIRT1 and depressive disorder.