To determine whether increased levels of LRH-1 can improve the course of disease in an immune-mediated model of colitis, VilCre;Rag2−/−;Rosa26-Flox-Stop-Flox hLRH-1 mice (Rag2−/−hLrh1IEC-TG) were generated to conditionally overexpress hLRH-1 in the intestinal epithelium in the presence of endogenous mLRH-1. This evidence concerns the gene NR5A2 and colitis.