JIB-04 selectively enhanced GC activation of a subset of GR target genes (Fig. 4b) that includes genes encoding proteins that help to mediate GC-induced death of lymphoid cells (Fig. 2a); the inhibitor also enhanced GC-induced death of the B-ALL cell line Nalm6 (Fig. 3). Here, NR3C1 is linked to acute lymphoblastic leukemia.