Similarly, a study analysing the transcriptome of the frontal cortex and cerebellum of patients with ALS demonstrating C9orf72 GGGGCC repeat expansions, identified a significant increase in transcripts from both classes of TEs (retrotransposons and DNA transposons) in the frontal cortex when compared with controls.40 Although C9orf72 expansion-negative patients with ALS also demonstrated a similar trend of increased TE expression in the frontal cortex, this was not statistically significant. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.