Another model system of ALS using Drosophila melanogaster, in which the expression of human TDP-43 in either neurons or glia resulted in protein aggregation, motor impairment and premature death, was used to investigate the relationship of TDP-43 and TEs further.39 Human TDP-43 overexpression was found to be correlated with elevated expression of members of the class of LTR retrotransposons and LINE families in Drosophila due to the loss of small interfering RNAs that act post-transcriptionally to repress these elements. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.