TNF and Hepatitis: TFA-JHDN-5 immunizations induced significantly more hepatitis (Fig. 2B and C), serum levels of TFA antibodies, CYP2E1 autoantibodies (Fig. 2D), and hepatic tissue levels of interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-17, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α by 3 weeks (Fig. 2E).