Based on our previous observation with the single-gene-deficient NOD models (which had lower atherogenic lipids and higher athero-protective HDL, and, more importantly, were not developing obvious atherosclerosis as found in B6 Apoe−/− mice), we compared lipid levels in the NOD Apoe−/−Ldlr−/− mice in a more intensive manner by analyzing lipids from mice on both chow food and a HFD. The gene discussed is APOE; the disease is atherosclerosis.