In further experiments, we compared the pathology of global aorta and aortic sinus sections, and found that both NOD Apoe−/−Ldlr−/− and B6 Apoe−/− mice develop severe atherosclerosis and that the percentage of plaque area did not differ (Fig. 3D-G, Fig. S3F-I). Here, APOE is linked to atherosclerosis.