APOE and atherosclerosis: As shown in Fig. 2C,D, the NOD Apoe−/− and NOD Ldlr−/− mice did not show a difference in atherosclerosis development and the narrowing area by plaques was not obvious (2.3% for both mutants), and B6 Apoe−/− mice had 7-fold more plaque formation in the lesion area (16.2%).