APOE and hyperlipidemia: Additional data plotting of hyperlipidemia in NOD Apoe−/−Ldlr−/− mice and NOD mice on a HFD for 4 and 8 weeks showed that TG was not significantly different, but TC and LDL was 9-fold and 30-fold lower in the control mice, respectively, and HDL was 30-fold higher in control animals (Fig. S3C).