However, utilization of genetically modified pigs as atherosclerosis models is still in its infancy, with the exception of PSCK9 transgenic pigs created by transposon integration and LDLR KO pigs generated by homology-directed recombination (HDR)-based methods (Al-Mashhadi et al., 2013; Davis et al., 2014; Li et al., 2016). This evidence concerns the gene LDLR and atherosclerosis.