Deletions, duplications, and various point mutations of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene, which encodes excitatory postsynaptic core scaffolding proteins [1], are causally associated with numerous neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorders (ASDs), bipolar disorder, intellectual disability, and schizophrenia [2–4]. The gene discussed is SHANK3; the disease is schizophrenia.