ARHGEF16 and neoplasm: Tumor xenografts in GLI2A, vehicle group developed much more rapidly than those of the control, vehicle group, while GANT61 greatly suppressed tumor growth due to GLI2 inhibition, as shown by the retarded tumor xenografts (Fig. 6a, b) and the reduced tumor size (Fig. 6c) and weight (Fig. 6d) in GLI2A, GANT61 group compared to those in GLI2A, vehicle group; the decreased protein levels of GLI2 and ARHGEF16 resulting from GANT61 treatment in Control, GANT61 and GLI2A, GANT61 groups compared to the vehicle groups were confirmed via western blotting (Fig. 6e).