CLDN5 and central nervous system cancer: Meanwhile, the co-transcription experimental results of miR-153 (miR-377) and FOXR2 proved that miR-153 (miR-377) overexpression increased the permeability of glioma-conditioned normal BBB, whereas FOXR2 overexpression decreased it; the dual overexpression of miR-153 (miR-377) and FOXR2 reversed the effects of overexpressed miR-153 (miR-377) alone in increasing the permeability of glioma-conditioned normal BBB and decreasing the expressions of ZO-1, occludin, and claudin-5.