In this study, we investigated the expression of piR-DQ590027, MIR17HG, miR-153, miR377, and FOXR2 in glioma-conditioned ECs (GECs) and then further explored the possible regulatory relationships among the above factors and their mechanisms of action on the permeability of glioma conditioned normal BBB. Here, FOXR2 is linked to central nervous system cancer.