As shown in Fig. 3b, quantitative analysis of CD31 expression in tumor tissue indicated that MVDs from the MET NVB group (4.17 ± 0.75) were different from that of the Endo-treated group of mice (7.33 ± 1.63, P < 0.05), and both were greater than that in the MET NVB + Endo group (1.50 ± 1.05, P < 0.05). Here, PECAM1 is linked to neoplasm.