A large body of evidence shows that treatment with bevacizumab induces significant changes in circulating biomarkers in different carcinomas (for example, colo-rectal cancers [21, 22], hepatocarcinoma [23], non-small cell lung cancers [24]), and our observed decrease in circulating VEGF is consistent with bevacizumab’s mechanism of action. This evidence concerns the gene VEGFA and carcinoma.