Tpm knock-down by the transfection of siRNA against Tpm1 and Tpm2 completely blocked TGF β-induced stress fiber formation in cultured mouse epithelial NMuMG and human cervical carcinoma SiHa cells, whereas the over-expression of Tm1.6 and Tm1.7 isoforms, derived from the Tpm1 gene, induced stress fibers even without addition of TGF β or other cytokines in human breast cancer MDA-MB-231 cells [86]. This evidence concerns the gene TPM1 and cervical carcinoma.