A study by Mottillo and colleagues utilized an inducible model for deletion of the two AMPK β subunits in adipocytes (iβ1β2AKO) [26], whereby deletion of AMPK exacerbated the insulin resistant phenotype in terms of hepatic steatosis and glucose tolerance in response to an HFD [23]. Here, PRKAA2 is linked to Hepatic steatosis.