αvβ3- and αvβ5-associated angiogenesis are respectively dependent on tumor cell-secreted fibroblast growth factor (bFGF)/tumor necrosis factor (TNF)α and VEGF through an amplification loop leading to αvβ3/αvβ5 overexpression on EC [145,146,147,148,149,150]. Here, TNF is linked to neoplasm.