In a recent study of several AML cell lines as well as CD33+ progenitor cells from AML and MDS patients, vorinostat induced gene expressions of COX2, p15, cFOS, genes that are downregulated in MDS and AML, and suppressed overexpressed genes cyclin D1 and c-MYC [50]. Here, CDKN2B is linked to acute myeloid leukemia.