ASXL1 and myeloid neoplasm: The polycomb repressive complex 2 (PRC2) silences H3K27 to H3K27me3, and several genes encoding components of the PRC2; EZH2, SUZ12, JARID2 and also mutations in ASXL1 coding for the PRC2 associated protein ASXL1, have been found to be mutated in myeloid malignancies (Table 1, Figure 4) [17,18,19,20,21,22,23,25,26].