Of note, it was reported that the Vectra DA test, a RA diagnostic test that measures 12 biomarkers in combination including VCAM-1, EGF, VEGF-A, IL-6, MMP-1, MMP-3, TNF-R1, YKL-40, Leptin, Resistin, SAA (serum amyloid) and CRP produced more accurate results in measuring the disease activity of the patients who are receiving RA treatment [115,116]. Here, CHI3L1 is linked to rheumatoid arthritis.