PRNP and prion disease: Besides the already known indirect interaction mediated by HSPGs between PrPC and non-integrin laminin receptor 37/67 kDa LR [95,96], we have recently found that PrPC is able to directly bind 37/67 kDa LR in neuronal cells, and that a small organic naphtol-derived compound possesses the ability to control both their binding and their trafficking in neuronal cells, thus representing a new small molecule to be tested, at least against prion disease [97].