In C57BL/6 mice, the top 10 KEGG pathways involved in weight reduction included (1) T-cell receptor signaling pathway, (2) axon guidance, (3) focal adhesion, (4) cell adhesion molecules, (4) endocytosis, (5) regulation of actin cytoskeleton, (6) renal cell carcinoma, (7) WNT signaling pathway, (8) VEGF signaling pathway, and (10) ERBB signaling pathway (Table 1). The gene discussed is VEGFA; the disease is renal cell carcinoma.