LEF1 and cancer: This procedure allowed us to identify numerous genes associated with super-enhancers, including various genes implicated in T-ALL and cancer pathogenesis in general, such as PTPRC (CD45), IKZF1 (Ikaros), CXCR4, ELF-1, IKZF2 (Helios), WNT8B, CCND3, RUNX1, HDAC1 and 7, SOCS1, CIITA, TCF12, LEF1, MYB, BCL2, and MYC (Figure 4).