The genetic profile of this cell line and leukemia cases containing t(8:14)(q24;q11) leading to MYC overexpression with NOTCH1wt/FBXW7wt/PTEN mutation or deletion resembles that of a recently described Notch1-independent mouse leukemia model arising following conditional Pten deletion [11]. The gene discussed is NOTCH1; the disease is leukemia.