In fact, putative super-enhancers were associated with transcription factors implicated in: (1) lymphocyte development, including T-lineage specification and maturation (IKZF1, IKZF2, ETS1); (2) T-ALL transcription factor oncogenes (MYB, MYC); (3) Wnt/ß-catenin signaling (LEF1); (4) cell cycle regulators (CCND3); (5) invasion/metastasis genes (CXCR4); and (6) anti-apoptotic members of the Bcl-2 family (BCL2). Here, BCL2 is linked to acute lymphoblastic leukemia.