The identification of key oncogene drivers regulated by super-enhancers in UP-ALL13 could help in determining the oncogenic drivers behind NOTCH1-independent T-ALL, which could cause a predisposition to disproportionate sensitivity to loss of bromodomain and extraterminal (BET) chromatin reader proteins such as the bromodomain-containing protein 4 (BRD4) cofactor. Here, NOTCH1 is linked to acute lymphoblastic leukemia.