Interestingly, the whole exome data analysis and Sanger sequencing based validation also revealed that gallbladder patient and a primary tumor derived NOZ cells harbor KRAS (G12V) mutation; the G415 gallbladder cells harbor KRAS (G13D) mutant allele; while the OCUG1 and SNU308 gallbladder cells were wild type for KRAS (Fig. 1b; Supporting Information Figure S2). This evidence concerns the gene KRAS and neoplasm.