Somatic mutations in genes previously reported to be altered in gallbladder cancer, including recurrent mutations in TP53 (35.2%), ERBB2, SF3B1, ATM and AKAP11 at 17.6% each were found to be mutated at comparable frequencies19, 37 (Fig. 1a and Supporting Information Table S3). The gene discussed is SF3B1; the disease is gallbladder cancer.