Additionally, consistent with a recent report that described alterations in ERBB2 and ERBB3 at a frequency of 9.8% and 11.8% respectively among Chinese gallbladder cancer,19, 37 we found recurrent activating ERBB2 (V777L) mutation in 6 of 44 gallbladder cancer samples with an overall mutation frequency of 13%, in addition to IHC based over expression across 24% (6 of 25) primary tumors. Here, ERBB2 is linked to gallbladder cancer.