Prior studies in human participants suggest a specific role for the PFC, especially orbito-frontal regions, and the striatum in RL.22 Furthermore, human genetic imaging studies have indicated an impact of genetic variation of CACNA1C genotype on fronto-limbic brain activation and connectivity, although the impact of CACNA1C genotype on brain activation during RL has not been specifically investigated.12,15,21,52 Polygenic risk scores for schizophrenia, to which genetic variants in CACNA1C contribute, have however been shown to influence fronto-striatal brain activation during RL.31 The gene discussed is CACNA1C; the disease is schizophrenia.