It is notable that some, although not all, reports of the effects of CACNA1C genotype on expression suggest that the common variants in humans may be associated with decreased CACNA1C expression.9,10 Furthermore deleterious mutations in L-type VGCCs have also been associated with risk for schizophrenia in exome-sequencing studies, further implicating low dosage of L-type VGCCs in risk for this disorder.13 The gene discussed is CACNA1C; the disease is schizophrenia.