The incidence of serrated lesions in the population is 5% to 8% (compared with 30% to 40% for adenomas) 6,7; moreover, with the exception of HPs, SPs are considered precursors of CRC due to BRAF mutation and CpG island methylator phenotype (CIMP) with or without microsatellite instability (MSI). The gene discussed is BRAF; the disease is colorectal carcinoma.