INS and Hypoglycemia: There was a low incidence of hypoglycemia in both treatment groups, which reflects the self-limiting modes of action of these agents, i.e. reduction in the amount of filtered glucose with decreasing blood glucose levels causes a low potential for hypoglycemia with dapagliflozin; and glucose-stimulated insulin secretion decreases in patients treated with saxagliptin as physiological glucose levels are approached, leading to a low risk of hypoglycemia.