According to a review by Nasarre and coauthors (6), three of the seven Sema3 family proteins – Sema3D, Sema3F, and Sema3G – have tumor-suppressive and anti-angiogenic properties, and three others – Sema3A, Sema3B, and Sema3E – show promoting and inhibiting effects on the development of different types of cancer and angiogenesis processes. Here, SEMA3E is linked to neoplasm.