SEMA3E and neoplasm: This statement was proven by several scientific studies, in one of which, for example, it was demonstrated that furin-like proteinases proteolytically activate the predominant form (p61) of Sema3E and promote tumor cell motility (10), whereas in other studies, the uncleavable form of Sema3E acts as anti-angiogenic and anti-metastatic factor (11,12).