Using a new adult cohort, PBMC from patients with positive peanut-specific IgE titers (>0.3 kUA/L), who are either symptomatic (patients with a clinical history consistent peanut allergy, n = 15) or non-symptomatic (patients who regularly ingest peanuts without experiencing any symptoms, n = 14) were cultured in vitro with either peanut extract or P19 pool for 14 days. Here, IGHE is linked to peanut allergic reaction.