MAP1LC3A and infection: As shown in Fig 2, the infection with the H1N1 and H9N2 could induce the characteristic distributional and morphological change of LC3, formed the LC3 punctate granules in the perinuclear area of the cytoplasm, and induced autophagy, effectively in the lung epithelial A549 cells (Fig 2A) and HPMECs (Fig 2B).