We found a strong correlation between IgG PB response and PD-1 upregulation within CXCR3+CCR6-CCR7- cTFH and CXCR3+CCR6-CCR7+ cTFH in HC who received Fluvax (Fig 9A and 9B), but not in CKD after Fluvax, or after HBV in any group. This evidence concerns the gene CXCR3 and chronic kidney disease.