To ask if Adrb2 directly suppresses insulin, we stimulated cultured MIN6 cells, an insulinoma-derived cell line analogous to β-cells, with epinephrine or norepinephrine, the endogenous ligands for Adrb2, or salbutamol, an Adrb2-specific agonist. This evidence concerns the gene ADRB2 and pancreatic insulinoma.